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Folic Acid 1000µg must first be converted to its active form by a series of biochemical steps, before it is able to be used by the body. Metafolin (calcium-L-methylfolate) requires no conversion because it is bioidentical to the bio-active form.
In other words, it is 'body-ready'. This can be useful for individuals whose bodies have difficulty converting folic acid to its active form. The active folate in this formulation promotes heart health. It also supports a healthy nervous system and the formation of healthy red blood cells.
Introducing SOLGAR FOLATE 1000µg (as Metafolin) Tablets:
Metafolin ((6S)-5-methyltetrahydrofolic acid, calcium salt or calcium-L-methylfolate) is the pure stable crystalline form of the naturally occurring predominant form of folate.
Increasing consumption of food and supplements containing provitamin folic acid does not necessarily solve the problem in all people. Various co-factor nutrients are required for the conversion of folic acid to folate and a person’s genetics also play an important role. The presence of genetic variations known as single nucleotide polymorphisms (SNP’s) in some people can mean that the body is not able to optimally convert folic acid into folate. Calcium-L-methylfolate completely bypasses the conversion steps that can otherwise be help up by missing cofactors and genetic variations, providing the body with the bioactive form of folate.
The English physician, Lucy Wills, worked in the slums of Bombay in the 1920’s and observed that a special form of anaemia could be treated with a yeast extract. It was only later that folate was recognised as the effective factor in such treatment, in 1941, Mitchell and colleagues suggested the name ‘Folic Acid’ (folium, Latin for leaf) for a factor showing vitamin-like properties. It took some decades to identify the nutritional factor involved and to elucidate its chemical structure. Today these vitamins of the B group are known as ‘Folates’. The metabolic roles of Folates are now largely known. Folates are important co-factors in carbon one-transfer reactions and are involved in two key metabolic pathways: DNA biosynthesis and the Methylation cycle.
Folates is the generic term comprising all the various chemical folate forms, including the provitamin, folic acid. Green leafy vegetables in particular are rich in folate. Metafolin (calcium-L-methylfolate) is the body’s preferred form of folate, because it is the naturally occurring predominant form of the folate vitamin, a readily bio available folate directly usable by the body (folic acid is a provitamin and needs to be activated.
Sufficient folate levels are critical throughout our entire life. Less than optimal folate intake has been implicated in a variety of complaints including anaemia, various forms of cardiovascular diseases (CVD), Alzheimer’s disease and osteoporosis. However, despite the importance of folates, the majority of the population has an insuffient folate intake. This is true even in countries with a mandatory food folate fortification with folic acid. The elderly population in particular does not reach the UK recommend daily allowance (RDA).
Folate 1000µg, bulking agent: mannitol, microcrystalline cellulose, anti-caking agents: vegetable stearate acid, vegetable cellulose, silica, vegetable magnesium stearate, cellulose gum
Each tablet provides: Folate 1000µg (as calcium-L-methylfolate as Metafolin*)
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