Indole-3-Carbinol

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Indole-3-carbinol is one of the major anticancer substances found in cruciferous (cabbage family) vegetables. It is a member of the class of sulphur-containing chemicals called glucosinolates.1 It is formed from parent compounds whenever cruciferous vegetables are crushed or cooked.2 3

Where is it found?

Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale.

Indole-3-carbinol has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings Health Concerns
2Stars

Cancer prevention (cervical cancer)
3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

As indole-3-carbinol is not an essential nutrient, no deficiency state exists.

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How much is usually taken?

Based upon preliminary studies it is estimated that the minimum amount required for the prevention of breast cancer is 300 to 400 mg daily.4

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Are there any side effects or interactions?

No side effects from indole-3-carbinol have been reported.

At the time of writing, there were no well-known drug interactions with indole-3-carbinol.

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References
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