HMB | Health Notes at WWSM | Health Information at WWSM

HMB

Also indexed as: Beta Hydroxy-Beta-Methylbutyrate

HMB (beta hydroxy-beta-methylbutyrate) is a metabolite of the essential amino acid leucine (one of the branched-chain amino acids).

Where is it found?

Small amounts of HMB are present in many foods of animal and plant origin, especially alfalfa and catfish. The amino acid leucine is metabolized into a compound called alpha-ketoisocaproate (KIC), which is then turned into HMB by the body. Dietary supplements of HMB are also available.

HMB has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	High cholesterol
	Athletic performance (for improving body composition with strength training in untrained people only) HIV support (in combination with glutamine and arginine)
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Science Ratings

Health Concerns

High cholesterol

Athletic performance (for improving body composition with strength training in untrained people only)

HIV support (in combination with glutamine and arginine)

Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars

Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star

For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

HMB is not an essential nutrient. The body creates HMB from leucine, so any diet containing sufficient amounts of leucine (most do) should lead to the adequate production of HMB. Limited evidence indicates that athletes may benefit from supplemental intake of HMB.

How much is usually taken?

Most people do not need to use HMB. For those involved in regular exercise who do choose to take this supplement, the research generally uses 3 grams of HMB per day in combination with resistive exercise, such as weight lifting.

Are there any side effects or interactions?

No safety issues have been reported in the limited number of studies currently available.

At the time of writing, there were no well-known drug interactions with HMB.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.

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Where is it found?

Who is likely to be deficient?

How much is usually taken?

Are there any side effects or interactions?