Timolol

Also indexed as: Apo-Timol, Apo-Timop, Betim, Blocadren, Gen-Timolol, Glau-opt, Novo-Timol, Nu-Timolol, PMS-Timolol, Tim-Ak, Timoptic, Timoptol

Combination drugs: Cosopt, Moducren, Prestim, Timolide

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Timolol is a beta-blocker drug used to lower blood pressure in people with hypertension, treat people after heart attacks, and prevent migraine headaches. Timolol is available alone and in a combination product used to lower blood pressure. Timolol is also available in eye drop and eye gel preparations used to lower high internal eye pressure due to glaucoma and other conditions.

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Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Beneficial May Be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication.

Co-Enzyme Q10

Depletion or interference

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

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An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

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Interactions with Dietary Supplements

Co-Enzyme Q10
In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral co-Enzyme Q10 (90 mg per day) was reported to reduce timolol-induced cardiovascular side effects without affecting intra-ocular pressure treatment.1

Potassium
Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the uptake of potassium from the blood into the cells,2 leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia.3 People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their doctor.

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Interactions with Herbs

Pleurisy root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.4

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Interactions with Foods and Other Compounds

Food
Timolol may be taken with or without food.5

Alcohol
Timolol may cause drowsiness, dizziness, lightheadedness, or blurred vision.6 Alcohol may intensify these effects and increase the risk of accidental injury. To prevent problems, people taking timolol should avoid alcohol.

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References
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