Etodolac | Health Notes at WWSM | Health Information at WWSM

Etodolac

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Also indexed as: Apo-Etodolac, Lodine, Ultradol

Etodolac is a member of the non-steroidal anti-inflammatory drug (NSAIDs) family. NSAIDs reduce inflammation (swelling), pain, and temperature. Etodolac is used to treat mild to moderate pain, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, bursitis, and other conditions.

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

May Be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.	Iron
May Be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication.	Copper* Liquorice
May Be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better.	Copper*
Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.	Lithium* Sodium* White willow*
Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.	Potassium
Reduced drug absorption/bioavailability	None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

Copper
Supplementation may enhance the anti-inflammatory effects of NSAIDs while reducing their ulcerogenic effects. One study found that when various anti-inflammatory drugs were chelated with copper, the anti-inflammatory activity was increased.¹ Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective amount of aspirin. These copper complexes are less toxic than the parent compounds, as well.

Iron
NSAIDs cause gastro-intestinal (GI) irritation, bleeding, and iron loss.² Iron supplements can cause GI irritation.³ However, iron supplementation is sometimes needed in people taking NSAIDs if those drugs have caused enough blood loss to lead to iron deficiency. If both iron and etodolac are prescribed, they should be taken with food to reduce GI irritation and bleeding risk.

Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts to treat mood disorders such as manic-depression (bipolar disorder). Most NSAIDs inhibit the excretion of lithium from the body, resulting in higher blood levels of the mineral, though sulindac may have an opposite effect.⁴ Since major changes in lithium blood levels can produce unwanted side effects or interfere with its efficacy, NSAIDs should be used with caution, and only under medical supervision, in people taking lithium supplements.

Potassium
NSAIDs have caused kidney dysfunction and increased blood potassium levels, especially in older people.⁵ People taking NSAIDs, including etodolac, should not supplement potassium without consulting with their doctor.

Sodium
Etodolac may cause sodium and water retention.⁶ It is healthy to reduce dietary salt intake by eliminating table salt and heavily salted foods.

Interactions with Herbs

Liquorice (Glycyrrhiza glabra)
The flavonoids found in the extract of liquorice known as DGL (deglycyrrhizinated liquorice) are helpful for avoiding the irritating actions NSAIDs have on the stomach and intestines. One study found that 350 mg of chewable DGL taken together with each dose of aspirin reduced gastro-intestinal bleeding caused by the aspirin.⁷ DGL has been shown in controlled human research to be as effective as drug therapy (cimetidine) in healing stomach ulcers.⁸

White willow bark (Salix alba)
White willow bark contains salicin, which is related to aspirin. Both salicin and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. The administration of salicylates like aspirin to individuals taking oral NSAIDs may result in reduced blood levels of NSAIDs.⁹ Though no studies have investigated interactions between white willow bark and NSAIDs, people taking NSAIDs should avoid the herb until more information is available.

Interactions with Foods and Other Compounds

Food
Etodolac should be taken with food to prevent gastro-intestinal upset.¹⁰

Alcohol
Etodolac may cause drowsiness, dizziness, or blurred vision.¹¹ Alcohol may intensify these effects and increase the risk of accidental injury. Use of alcohol during etodolac therapy increases the risk of stomach irritation and bleeding. People taking etodolac should avoid alcohol.

References
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.

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Interactions with Dietary Supplements

Interactions with Herbs

Interactions with Foods and Other Compounds