Diarrhea | Health Notes at WWSM | Health Information at WWSM

Diarrhoea

Also indexed as: Stools (Loose)

While persistent or severe cases may need special care, for common diarrhoea discomfort relief just takes time and a few well-chosen remedies. According to research or other evidence, the following self-care steps may be helpful:

Refuel and rehydrate
Replace lost fluids and replenish electrolytes by drinking sports drinks or other rehydration formulas, or eating vegetable soup

Forego offending foods and supplements
Limit your intake of fruit juice, fructose, sorbitol, lactose, and coffee, and avoid large amounts of vitamin C and magnesium supplements to prevent diarrhoea that may be caused by poor absorption of these substances

Go with probiotics
Try “beneficial bacteria” supplementation to help with recovery and prevent recurrences; take 500 mg of Saccharomyces boulardii one to four times a day, or 3 billion colony-forming units of probiotic bacteria one to three times a day

Rely on lactase
If you think you may suffer from lactose intolerance, try a digestive enzyme–containing lactase when drinking or eating milk products

Make time for a check-up
See your doctor if diarrhoea continues for more than a few days or if you experience other abdominal symptoms

These recommendations are not comprehensive and are not intended to replace the advice of your doctor or chemist. Continue reading the full diarrhoea article for more in-depth, fully-referenced information on medicines, vitamins, herbs, and dietary and lifestyle changes that may be helpful.

About diarrhoea

Diarrhoea is any attack of frequent, watery stools.

Diarrhoea can be triggered by many different conditions. Acute diarrhoea is often caused by an infection and may require medical management. The primary role of nutrition in acute diarrhoea is to prevent depletion of fluid, sodium, potassium, and calories. Replenishment of all four has been achieved with “rehydration solutions” and with a variety of foods, from salted carrot soup to peeled scraped apple to rice gruel. However, diarrhoea severe enough to necessitate the use of rehydration solutions requires direct medical supervision. Therefore, nutritional approaches to overcoming depletion of fluid, sodium, potassium, and calories are not discussed here, but rather should be discussed with a doctor. Diarrhoea-induced low blood sugar, dehydration, or electrolyte imbalance can be serious or even life-threatening, particularly if prolonged in children.

A doctor should be consulted if diarrhoea continues for more than a few days, as it may indicate a more serious health condition. Diarrhoea alternating with constipation may be a sign of irritable bowel syndrome (IBS).

Product ratings for diarrhoea

Science Ratings	Nutritional Supplements	Herbs
	Lactase (for lactose-intolerant people) Multiple vitamin-mineral (to protect against deficiencies) Probiotics (for infectious and antibiotic-associated diarrhoea)
	Brewer’s yeast (for infectious diarrhoea) Colostrum Fibre Glutamine	Carob Psyllium Sangre de drago Tormentil root extract (for rotavirus infection)
	Folic acid Vitamin A Zinc	Barberry Bilberry Blackberry Bladderwrack Blueberry Chamomile Cranesbill Goldenseal Marshmallow Oak Oregon grape Periwinkle Red raspberry Sweet Annie Tylophora
See also: Homoeopathic Remedies for Diarrhoea
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

What are the symptoms?

Normal bowel habits vary considerably from person to person depending on age, diet, cultural factors, and individual physiology. However, loose watery stools occurring three or more times in one day is generally considered abnormal. In some instances, diarrhoea may be accompanied by cramping abdominal pain, nausea, vomiting, fever, loss of appetite, and bloody or foul-smelling stools.

Dietary changes that may be helpful

Some foods contain sugars that are absorbed slowly, such as fructose in fruit juice or sorbitol in dietetic confectionery. Through a process called osmosis, these unabsorbed sugars hold onto water in the intestines, sometimes leading to diarrhoea.¹ By reading labels, people with chronic non-infectious diarrhoea can easily avoid fruit juice, fructose, and sorbitol to see if this eliminates the problem.

People who are lactose intolerant—meaning they lack the enzyme needed to digest milk sugar—often develop diarrhoea after consuming milk or ice cream. People whose lactose intolerance is the cause of diarrhoea will rid themselves of the problem by avoiding milk and ice cream or in many cases by taking lactase, the enzyme needed to digest lactose. Lactase is available in a variety of forms in pharmacies (and in grocery stores in the form of lactase-treated milk).

Large amounts of vitamin C or magnesium found in supplements can also cause diarrhoea, although the amount varies considerably from person to person. Unlike infectious diarrhoea, diarrhoea caused by high amounts of vitamin C or magnesium is not generally accompanied by other signs of illness. The same is true when the problem comes from sorbitol or fructose.² In these cases, avoiding the offending supplement or food brings rapid relief.

Drinking a few cups of coffee per day causes diarrhoea in some people.³ People with chronic diarrhoea who drink coffee should avoid all coffee for a few days to evaluate whether coffee is the culprit.

Allergies and food sensitivities are common triggers for diarrhoea.⁴ For example, some babies suffer diarrhoea when fed cow’s milk-based formula but improve when switched to soya-based formula.⁵ People with chronic diarrhoea not attributable to other causes should discuss the possibility of food sensitivity with a doctor.

Some doctors recommend a diet called the BRAT diet for acute bouts of diarrhoea. BRAT stands for bananas, rice, apples and toast. These foods are mild, well-tolerated and good sources of fibre, potassium and other nutrients that may be helpful in diarrhoea. The efficacy of this diet has not been evaluated in clinical trials.

Other therapies

Rest, along with fluid replacement using Pedialyte®, Ceralyte®, or Infalyte®, is often recommended. Severe diarrhoea, especially in children and the elderly, may require hospitalisation for urgent fluid and electrolyte replacement in order to correct dehydration.

Vitamins that may be helpful

An organism related to brewer’s yeast, Saccharomyces boulardii (Sb), is widely used in Europe to prevent antibiotic-induced diarrhoea. It is also available as a supplement in the United States. Animal research with Sb shows interference with Clostridium difficile, a common bacterial cause of diarrhoea.⁶ In double-blind trials, Sb has prevented antibiotic-induced⁷ and other forms of infectious diarrhoea.⁸ An intake of 500 mg four times per day has been used in some of this research. Sb has also helped tourists prevent traveller’sdiarrhoea, according to double-blind research.⁹ In one trial, positive results were obtained at amounts as low as 150–450 mg per day.¹⁰ Even diarrhoea caused by Crohn’s disease has partially responded to Sb supplementation in double-blind research.¹¹ While not every trial shows efficacy,¹² the preponderance of evidence clearly supports the use of Sb in people with diarrhoea caused by antibiotics or infection. Seriously ill patients should consult with their doctor before supplementing with Sb, as rare but serious cases of infection caused by Sb in such patients has been reported.¹³

Beneficial bacteria, such as lactobacilli and bifidobacteria, normally live in a healthy colon, where they inhibit the over-growth of disease-causing bacteria.¹⁴ Diarrhoea flushes intestinal microorganisms out of the digestive tract, leaving the body vulnerable to opportunistic infections. Replenishing with acidophilus and other beneficial probiotic bacteria can help resolve the diarrhoea and prevent new infections.¹⁵ The effective amount of probiotic bacteria depends on the strain used, as well as the concentration of viable organisms.

The combination of bifidobacteria and Strep thermophilus (found in certain yoghurts) dramatically reduces the incidence of acute diarrhoea in hospitalised children.¹⁶ Active-culture yoghurt, milk fermented with Lactobacillus casei and other sources of probiotic bacteria may prevent antibiotic-induced diarrhoea.¹⁷ ¹⁸ ¹⁹

As mentioned in the dietary changes section above, if lactose intolerance is the cause of diarrhoea, supplemental use of lactase prior to consuming milk or milk-containing products can be helpful.²⁰ Cheese rarely has enough lactose to cause symptoms in lactose-intolerant people. Lactase products are available that can be chewed while drinking milk or added to milk directly.

The malabsorption problems that develop during diarrhoea can lead to deficiencies of many vitamins and minerals.²¹ For this reason, it makes sense for people with diarrhoea to take a multivitamin-mineral supplement. Two of the nutrients that may not be absorbed efficiently as a result of diarrhoea are zinc and vitamin A, both needed to fight infections. In third world countries, supplementation with zinc and vitamin A has led to a reduction in, or prevention of, infectious diarrhoea in children.²² Whether such supplementation would help people in better nourished populations remains unclear.

Brewer’s yeast supplementation has been shown to alter immune function and the flora living in the intestine, and may relieve infectious diarrhoea. Three capsules or tablets of brewer’s yeast three times per day for two weeks was reported to improve three cases of infectious diarrhoea caused by Clostridium difficile.²³ Animal research has confirmed that brewer’s yeast helps fight this unfriendly bacterium.²⁴ (Note that real brewer’s yeast is not identical to nutritional, or torula, yeast and that when asking for “brewer’s yeast” in health food stores, people are often directed toward these other products. Real brewer’s yeast is bitter, whereas other health food store yeasts have a more pleasant taste.)

Colostrum might be useful for certain types of infectious diarrhoea. In a double-blind trial, children with diarrhoea caused by a rotavirus were treated with immunoglobulins extracted from colostrum derived from cows immunized with rotavirus. Compared with the placebo, colostrum extract significantly reduced the amount of diarrhoea and the amount of oral rehydration solution required. The rotavirus was eliminated from the stool significantly more rapidly in the colostrum group than in the placebo group (1.5 days, vs. 2.9 days).²⁵

In addition to a positive effect against acute rotavirus diarrhoea,²⁶ there is also evidence that specific forms of colostrum (derived from specially immunized cows or those with confirmed presence of specific antibodies) are effective against diarrhoea caused by Cryptosporidium parvum, Helicobacter pylori, Escherichia coli, and Clostridium difficile.²⁷ ²⁸ ²⁹ ³⁰ ³¹ However, it is not known whether commercially-available colostrum provides significant amounts of the specific immunoglobulins that are active against these organisms. Furthermore, unless the immunoglobulins are present in high enough concentrations, the preparation is not likely to be effective.³²

In a double-blind study of children (ages six months to two years) with acute diarrhoea, supplementing with glutamine significantly reduced the duration of diarrhoea by 26%.³³ Children were given 136 mg of glutamine per pound of body weight per day for seven days. Glutamine appeared to work by improving the health of the intestinal lining, rather than through any effect on the immune system.

While fibre from dietary or herbal sources is often useful for constipation, it may also play a role in alleviating diarrhoea.

Acute diarrhoea can damage the lining of the intestine. Folic acid can help repair this damage. In one preliminary trial, supplementing with very large amounts of folic acid (5 mg three times per day for a few days) shortened the duration of acute infectious diarrhoea by 42%.³⁴ However, a double-blind trial failed to show any positive effect with the same level of folic acid.³⁵ Therefore, evidence that high levels of folic acid supplementation will help people with infectious diarrhoea remains weak.

It is known vitamin A supplements support immune function and prevent infections. This is true, however, only under some circumstances. Vitamin A supplementation can also increase the risk of infections, according to the findings of a double-blind trial.³⁶ In a study of African children between six months and five years old, a 44% reduction in the risk of severe diarrhoea was seen in those children given four 100,000–200,000 IU supplements of vitamin A (the lower amount for those less than a year old) during an eight-month period. On further investigation, the researchers discovered that the reduction in diarrhoea occurred only in children who were very malnourished. For children who were not starving, vitamin A supplementation actually increased the risk of diarrhoea compared with the placebo group. The vitamin A-supplemented children also had a 67% increased risk of coughing and rapid breathing, and signs of further lung infection, although this problem did not appear in children infected with the AIDS virus. These findings should be of concern to American parents, whose children are not usually infected with HIV or severely malnourished. Such relatively healthy children fared poorly in the African trial in terms of both the risk of diarrhoea and the risk of continued lung problems. Vitamin A provided no benefit to the well-nourished children. Therefore, it makes sense not to give vitamin A supplements to children unless there is a special reason to do so, such as the presence of a condition causing malabsorption (e.g., coeliac disease).

Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.

Herbs that may be helpful

The following recommendations are for milder forms of diarrhoea. For more serious cases of diarrhoea, proper medical evaluation and monitoring should occur before taking any herbal supplements.

Carob is rich in tannins that have an astringent or binding effect on the mucous membranes of the intestinal tract. A double-blind trial has suggested it may be particularly useful for young children and babies with diarrhoea.³⁷ Some healthcare professionals recommend 15 grams of carob powder is mixed with apple sauce (for flavour) when given to children. Carob can also be used for treating adult diarrhoea.

While fibre from dietary or herbal sources is often useful for constipation, it may also play a role in alleviating diarrhoea. For example, 9–30 grams per day of psyllium seed (an excellent source of fibre) makes stool more solid and can help resolve symptoms of non-infectious diarrhoea.³⁸ Alginic acid, one of the major constituents in bladderwrack(Fucus vesiculosus), is a type of dietary fibre and as a result may potentially help relieve diarrhoea. However, human studies have not been done on how effective bladderwrack is for this condition.

An extract from stem bark latex of Sangre de drago (Croton lechleri), a herb from the Amazon basin of Peru, has demonstrated significant anti-diarrhoeal activity in preliminary³⁹ ⁴⁰ and double-blind trials. Double-blind research has demonstrated the extract’s effectiveness for traveller’sdiarrhoea,⁴¹ non-specific diarrhoea,⁴² and diarrhoea associated with HIV infection and AIDS.⁴³ ⁴⁴ For traveller’sdiarrhoea and nonspecific diarrhoea, amounts ranging from 125 mg to 500 mg taken four times daily for two days have proven effective. However, in one trial, only the 125 mg four times daily amount (but not higher amounts) was effective for acute nonspecific diarrhoea.⁴⁵ The reasons for the failure of higher amounts in this study is not known. Very high amounts of these extracts (350–700 mg four times daily for seven or more days) were used in the trials involving people with HIV and AIDS. Such levels of supplementation should always be supervised by a doctor. Most of this research on Sangre de Drago is unpublished, and much of it is derived from manufacturers of the formula. Further double-blind trials, published in medical journals, are needed to confirm the efficacy reported in these studies.

Tormentil root (Potentilla tormentilla) is a herb that has been used for many years in different European folk medicines for the treatment of diarrhoea. In a double-blind study of children with diarrhoea caused by rotavirus infection, the duration of diarrhoea averaged three days in children who received tormentil root extract, compared with five days in those who received a placebo.⁴⁶ No adverse effects were seen. The amount of tormentil root extract used was 3 drops for every year of life, taken three times a day until diarrhoea stopped, or for a maximum of five days.

Other astringent herbs traditionally used for diarrhoea include blackberry leaves, blackberry root bark, blueberry leaves, and red raspberry leaves.⁴⁷ Raspberry leaves are high in tannins and, like blackberry, may relieve acute diarrhoea. A close cousin of the blueberry, bilberry, has been used traditionally in Germany for adults and children with diarrhoea.⁴⁸ Only dried berries or juice should be used—fresh berries may worsen diarrhoea.

Cranesbill has been used by a few of the indigenous tribes of North America to treat diarrhoea. The tannins in cranesbill likely account for the anti-diarrhoeal activity⁴⁹ —although there has been little scientific research to clarify cranesbill’s constituents and actions.

In laboratory experiments, a tannin in oak, known as ellagitannin, inhibited intestinal secretion,⁵⁰ which may help resolve diarrhoea. Oak is well regarded in Germany, where it is recommended (along with plenty of electrolyte-containing fluids) to treat mild, acute diarrhoea in children.⁵¹

Due to of its supposed antimicrobial activity, goldenseal has a long history of use for infectious diarrhoea. Its major alkaloid, berberine (also found in barberry and Oregon grape), has been shown to improve infectious diarrhoea in some double-blind trials.⁵² Negative studies have generally focused on people with cholera, while positive studies investigated viral diarrhoea or diarrhoea due to strains of E. coli. These studies generally used 400–500 mg berberine one to three times per day. Because of the low amount of berberine in most goldenseal products, it is unclear how effective the whole root or root extracts would be in treating diarrhoea.

Chamomile may reduce intestinal cramping and ease the irritation and inflammation associated with diarrhoea, according to test tube studies.⁵³ Chamomile is typically taken as a tea. Many doctors recommend dissolving 2–3 grams of powdered chamomile or adding 3–5 ml of a chamomile liquid extract to hot water and drinking it three or more times per day, between meals. Two to three teaspoons (10–15 grams) of the dried flowers can be steeped in a cup of hot water, covered, for ten to fifteen minutes as well.

Tylophora has been used traditionally in the Ayurvedic system for diarrhoea probably due to its anti-inflammatory and antimicrobial actions, although human studies have not confirmed this use.

Herbs high in mucilage, such as marshmallow or slippery elm, may help reduce the irritation to the walls of the intestinal tract that can occur with diarrhoea. A usual amount taken is 1,000 mg of marshmallow extract, capsules, or tablets three times per day. Marshmallow may also be taken as a tincture in the amount of 5–15 ml three times daily.

Sweet annie has been used traditionally to treat infectious diarrhoea and malaria. However, more modern studies have used the isolated constituent artemisinin and it is unclear how effective the herb is in managing diarrhoea.

Are there any side effects or interactions?
Refer to the individual herb for information about any side effects or interactions.

Integrated approaches that may be helpful

Other integrative approaches that may be helpful: Acupuncture may be useful for the treatment of diarrhoea, particularly in babies. A preliminary study of acupuncture treatment in 1,050 cases of infantile diarrhoea found 95% were relieved with one to three treatments.⁵⁴ Similar results have been reported in other preliminary trials⁵⁵ ⁵⁶ and case reports.⁵⁷ ⁵⁸ A controlled trial of acupuncture for the treatment of infantile diarrhoea compared scalp acupuncture or traditional body acupuncture with drug therapy, primarily antibiotics. The cure rate for scalp and body acupuncture was significantly higher (90% and 89%) than that of drug treatment (46%).⁵⁹

References
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1. Hyams JS, Etienne NL, Leichtner AM, Theuer RC. Carbohydrate malabsorption following fruit juice ingestion in young children. Pediatr 1988;82:64–8.

2. Barness LA. Safety considerations with high ascorbic acid dosage. Ann NY Acad Sci 1975;258:523–8 [review].

3. Babb RR. Coffee, sugars and chronic diarrhea. Postgrad Med 1984;75:82, 86–7.

4. James JM, Burks AW. Food-associated gastrointestinal disease. Curr Opin Pediatr 1996;8:471–5 [review].

5. Bowie MD, Hill ID, Mann MD. Response of severe infantile diarrhoea to soya-based feeds. S Afr Med J 1988;73:343–5.

6. Pothoulakis C, Kelly CP, Joshi MA, et al. Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology 1993;104:1108–15.

7. Surzwicz CM, Elmer GW, Speelman P, et al. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989;96:981–8.

8. Bleichner G, Blehaut H, Mentec H, Moyse D. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A muticenter, randomized, double-blind placebo-controlled trial. Intensive Care Med 1997;23:517–23.

9. Kollaritsch H, Holst H, Grobara P, Widermann G. Prevention of traveler’s diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study. Fortschr Med 1993;111:152–6 [in German].

10. Kirchelle A, Fruhwein N, Toburen D. Treatment of persistent diarrhea with S. boulardii in returning travelers. Results of a prospective study. Forstchr Med 1996;114:136–40 [in German].

11. Plein K, Hotz J. Therapeutic effects of Saccharomyces on mild residual symptoms in a stable phase of Crohn’s disease with special respect to chronic diarrhea—a pilot study. Z Gastroenterol 1993;31:129–34.

12. Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. J Infect 1998;36:171–4.

13. Piarroux R, Millon L, Bardonnet K, et al. Are live saccharomyces yeasts harmful to patients? Lancet 1999;353:1851–2 [letter].

14. Poupard JA, Hussain J, Norris RF. Biology of the bifidobacteria. Bact Rev 1973;37:136–65.

15. Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000;95:S16–8 [review].

16. Saavedra JM, Bauman NA, Oung I, et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994;344:1046–9.

17. Colombel JF, Cortot A, Neut C, Romond C. Yogurt with Bifidobacterium longum reduces erythromycin-induced gastrointestinal effects. Lancet 1987;2:43 [letter].

18. Pedone CA, Bernabeu AO, Postaire ER, et al. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract 1999;53:179–84.

19. Saavedra J. Probiotics and infectious diarrhea. Am J Gastroenterol 2000;95:S16–8 [review].

20. Montes RG, Perman JA. Lactose intolerance. Postgrad Med 1991;89:175–84 [review].

21. Werbach MR. Nutritional influences on Illness, 2d ed. Tarzana, CA: Third Line Press, 1993, 256–61 [review].

22. Bhan MK, Bhandari N. The role of zinc and vitamin A in persistent diarrhea among infants and young children. J Pediatr Gastroenterol Nutr 1998;26:446–53 [review].

23. Schellenberg D, Bonington A, Champion C, et al. Treatment of Clostridium difficile diarrhea with brewer’s yeast. Lancet 1994;343:171–2 [letter].

24. Izadnia F, Wong CT, Kocoshis SA. Brewer’s yeast and Saccharomyces boulardii both attenuate Clostridium difficile-induced colonic secretion in the rat. Dig Dis Sci 1998;43:2055–60.

25. Sarker SA, Casswall TH, Mahalanabis D, et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J 1998;17:1149–54.

26. Mitra AK, Mahalanabis D, Ashraf H, et al. Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double- blind, controlled clinical trial. Acta Paediatr 1995;84:996–1001.

27. Okhuysen PC, Chappell CL, Crabb J, et al. Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum. Clin Infect Dis 1998;26:1324–9.

28. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348–54.

29. Casswall TH, Sarker SA, Albert MJ, et al. Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Aliment Pharmacol Ther 1998;12:563–8.

30. Huppertz HI, Rutkowski S, Busch DH, et al. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin-producing E. Coli, and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr 1999;29:452–6.

31. Warny M, Fatimi A, Bostwick EF, et al. Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut 1999;44:212–7.

32. Brines RD, Brock JH. The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion. Biochim Biophys Acta 1983;759:229–35.

33. Yalcin SS, Yurdakok K, Tezcan I, Oner L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J Pediatr Gastroenterol Nutr 2004;38:494–501.

34. Haffejee IE. Effect of oral folate on duration of acute infantile diarrhoea. Lancet 1988;2:334–5 [letter].

35. Ashraf H, Rahman MM, Fuchs GJ, Mahalanabis D. Folic acid in the treatment of acute watery diarrhoea in children: a double-blind, randomized, controlled trial. Acta Pædiatr 1998;87:1113–5.

36. Fawzi WW, Mbise R, Spiegelman D, et al. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. J Pediatr 2000;137:660–7.

37. Loeb H, Vandenplas Y, Wursch P, Guesry P. Tannin-rich pod for treatment of acute-onset diarrhea. J Pediatr Gastroenterol Nutr 1989;8:480–5.

38. Eherer AH, Porter J, Fordtran JS. Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. Gastroenterol 1993;104:1007–12.

39. Koch J, Tuveson J, Carlson T, Schmidt J. SB-300: a new and effective therapy for HIV-associated diarrhea. Poster presented at the Seventh European Conference on Clinical Aspects and Treatment of HIV-Infection, Lisbon, Portugal, October 23–27, 1999.

40. DuPont HL, Tidmarsh G. An open label pilot study to investigate the safety and effectiveness of orally administered Provir (SP-303) capsules in the symptomatic treatment of acute nonspecific diarrhea and traveler’s diarrhea. South San Francisco, CA: Shaman Pharmaceuticals, 1998, unpublished.

41. Dicesare D, DuPont HL, Mathewson JJ, et al. A double-blind, randomized, placebo-controlled study of SP-303 in the symptomatic treatment of acute diarrhea among travelers to Mexico and Jamaica. Abstract presented at the Infectious Diseases Society of America, 36th Annual Meeting, Denver, CO, November 10, 1998.

42. Ettedgui G, Schael IP, Porter S, Pennington J. A double-blind, randomized, placebo-controlled, multi-dose, phase II study to assess the safety and efficacy of SP-303 in the symptomatic treatment of acute diarrhea among adult residents of Venezuela: oral administration of 125 mg, 250 mg, or 500 mg of SP-303 given every 6 hours for 48 hours. South San Francisco, CA: Shaman Pharmaceuticals, 1998, unpublished.

43. Holodniy M, Koch J, Mistal M, et al. A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS. Am J Gastroenterol 1999;94:3267–73.

44. Koch J. A phase III, double-blind, randomized, placebo-controlled multi-center study of SP-303 (Provir™) in the symptomatic treatment of diarrhea in patients with acquired immunodeficiency syndrome (AIDS). Posters presented at the 13th international AIDS Conference in Durba, South Africa, July 14, 2000.

45. Ettedgui G, Schael IP, Porter S, Pennington J. A double-blind, randomized, placebo-controlled, multi-dose, phase II study to assess the safety and efficacy of SP-303 in the symptomatic treatment of acute diarrhea among adult residents of Venezuela: oral administration of 125 mg, 250 mg, or 500 mg of SP-303 given every 6 hours for 48 hours. South San Francisco, CA: Shaman Pharmaceuticals, 1998, unpublished.

46. REF: Subbotina MD, Timchenko VN, Vorobyov MM, et al. Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children: a randomized, double blind, controlled trial. Pediatr Infect Dis J 2003;22:706–11.

47. Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York: Pharmaceutical Products Press, 1994, 51–4.

48. Weiss RF. Herbal Medicine. Gothenburg, Sweden: Ab Arcanum and Beaconsfield, UK: Beaconsfield Publishers Ltd, 1988, 101–2.

49. Duke JA. CRC Handbook of Medicinal Plants. Boca Raton, FL: CRC Press, 1985, 209.

50. Konig M, Scholz E, Hartmann R, et al. Ellagitannins and complex tannins from Quercus petraea bark. J Nat Prod 1994;57:1411–5.

51. Schilcher H. Phytotherapy in Paediatrics. Stuttgart, Germany: Medpharm Scientific Publishers, 1997, 49–50.

52. Khin-Maung-U, Myo-Khin, Nyunt-Nyunt-Wai, et al. Clinical trial of berberine in acute watery diarrhoea. Br Med J 1985;291:1601–5.

53. Achterrath-Tuckerman U, Kunde R, et al. Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan® on isolated guinea pig ileum. Planta Med 1980;39:38–50.

54. Su Z. Acupuncture treatment of infantile diarrhea: a report of 1050 cases. J Tradit Chin Med 1992;12:120–1.

55. Feng WL. Acupuncture treatment for 30 cases of infantile chronic diarrhea. J Tradit Chin Med 1989;9:106–7.

56. Lin YC. Observation of therapeutic effects of acupuncture treatment in 170 cases of infantile diarrhea. J Tradit Chin Med 1987;7:203–4.

57. Cao Y. Personal experience on acupuncture treatment of diarrhea. J Tradit Chin Med 1990;10:163–7.

58. Cao Y. Personal experience on acupuncture treatment of diarrhea. J Tradit Chin Med 1990;10:251–6.

59. Lin Y, Zhou Z, Shen W, et al. Clinical and experimental studies on shallow needling technique for treating childhood diarrhea. J Tradit Chin Med 1993;13:107–14.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.

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